Buy custom the role of gaba and nmda in the epileptic brain
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| Topic: |
Science
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| Number of pages / Number of words: |
8 / 2134 |
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In adult rats GABAergic inhibition exerts a powerful inhibitory drive of CA3 pyramidal neurons and prevents the spread of excitation. Once the inhibition has been reduced by Bicuculline (BIC), a GABA A antagonist, causes excitatory collaterals to prevail and epileptiform discharges are generated. In contrast in postnatal weeks 5 to 7 in rats, both spontaneous and electrically induced activity of CA3 neurons is characterized by the presence of giant depolarization potentials (GDPs) that is driven by the network (Roustem, 22)...
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In contrast in postnatal weeks 5 to 7 in rats, both spontaneous and electrically induced activity of CA3 neurons is characterized by the presence of giant depolarization potentials (GDPs) that is driven by the network (Roustem, 22). These findings that in neonatal rats GABA constitutes the main excitatory drive to pyramidal cells, demonstrates that during development neurotransmitters may dramatically change function...
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