Buy custom The benefits and side effects of Interferon alpha
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| Topic: |
Science
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| Number of pages / Number of words: |
19 / 5055 |
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All IFN-alphas contain four cysteine residues (positions 1, 29, 99 and 139), which are involved in disulfide bridges.2 As stated earlier, IFN-alpha gene expression is induced upon viral infections. This induction is transient, involving transcritiptional activation by several factors that bind to upstream regulatory cis-elements...
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The region involved in virus inducibility of the human IFN-alpha genes is known as the virus-inducible element or VRE. After viral infection, several events occur, including posttranslational activation by phosphorylation of inactive transcription factor families, including nuclear factor (NF)-kB, ATF-2/c-Jun, and interferon regulatory factors (IRFs), which activate immediate early genes (that encode IFN-alpha)...
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