Buy custom Studying of Alzheimer?¦s disease
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Science
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11 / 3005 |
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The PDAPP mice expressed very similar property that of the AD in ultra structures, pathway of plaque formation, and even the degeneration of memory by testing with maze task with increase aging.
Other lines of mouse with similar over express of human APP has been developed with slight different mutation or different promoter control for the amyloid precursor protein...
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These other transgenic mouse shows difference in percentage of neuron loss and plaque formation at different age, however they all show the general memory deficits symptoms expressed like the AD.
Interaction of presenilin and APP
APP mutations only cause a fraction of the reason for familial AD. It is believed that mutation in presenilins1 and 2 can also contribute to the cause of AD by altering the process of APP to favor the production of the fibrillogenic A?]42...
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