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However, there have been cases that show people with sickle cell trait can exhibit sickle cells under extreme conditions of physical stress or low oxygen supply.
As sickle cell disease is a genetic disorder, anyone whose parent has the gene for sickle cell disease has the chance of at least having the sickle cell trait...
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Sickle cell anemia is a worldwide health problem with occurrences in Africa, South America, Latin America, the West Indies, Greece, Spain, Italy, and Turkey--and in people who live around the Mediterranean Sea. In the United States, one out of every 10 African-Americans has the sickle cell trait, and one out of every 400 African-Americans has sickle cell anemia...
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