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| Topic: |
Science
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| Number of pages / Number of words: |
14 / 3838 |
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It is believed that the NSAID-induced inhibition of COX-1 in the gastrointestinal mucosa leads to the development of serious gastrointestinal complications such as ulcers and bleeds. The selective COX-2 inhibitors were developed to inhibit preferentially the COX-2 enzyme while sparing COX-1, with the premise that this would prevent serious gastrointestinal toxicity...
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However, recent studies have shown an unequivocal increase in risk of cardiovascular thrombotic events in patients treated with these drugs [1-5].
It is unclear whether the greater risk of AMI seen with selective COX-2 inhibitors is a 'class' effect of all NSAIDs. Like aspirin, nonselective NSAIDs inhibit COX-1, albeit temporarily, and they have generally been assumed to be antithrombotic or to have no cardiovascular adverse effect [8]...
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