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Science
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| Number of pages / Number of words: |
4 / 910 |
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This inactivated state = anergy
8. Hypersensitivity
? consists of an immune response directed against NON-INFECTIOUS agents
o innocuous particles, proteins, etc.
o examples seen in: pollen allergies, food allergies, drug allergies, etc.
o self proteins
? leading to autoimmunity type I is generally not implicated in autoimmunity, while types II, III &IV are NOTE: autoimmunity is utterly dependent upon the adaptive immune response
? 4 types of hypersensitivity can be delineated:
I) Anaphylactic/IgE-mediated allergic rhinitis, food allergies and systemic anaphylaxis
II) Cytotoxic: mediated by IgG directed against cell- or matrix-associated antigens autoimmune hemolytic anemia, Graves disease, myasthenia gravis
III) Immune complex-mediated - IgG antibodies are directed against soluble antigens, leading to the formation of immune complexes
systemic lupus erythematosis
o antibodies are directed against nuclear antigens such as nucleosomes, the spliceosome and ribonucleoproteins
o patients often present with butterfly rash on cheeks
o deposition of immune complexes happens at many various sites, including:
a...
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vasculature--leading to vasculitis
b. skin, especially in sun-exposed areas
c. joints, CNS, spleen, serosal membranes, heart
d. most importantly (and most common cause of death with SLE): the kidneys
o DNA-anti DNA immune complexes accumulate in the kidneys and lead to nephritis
rheumatoid arthritis
o RA is both a type III and type IV response
o in ~80% of patients with RA, patients develop immune complexes that consist of IgM that binds to IgG (reason unknown)...
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A critical review of the ways in which marketing thought is evolving in response to current trends in the services marketing environment.
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