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| Topic: |
Science
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| Number of pages / Number of words: |
13 / 3477 |
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Rates and extent of the paracellular transport are, therefore, highly
influenced by the structure and size of the tight junctions as well as by the
size of the molecules. Only small and hydrophilic drugs can pass between the
cells rapidly and completely; permeation of larger molecules can be limited
proportionally to their size and lipophilicity (Hillgren et al...
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1995).
Simple assay methods are needed for drug absorption studies. Excised intestinal
tissue, isolated cells, membrane vesicles and in vivo models have distinct
limitations, which have been previously discussed in detail (Audus et al. 1990;
Artursson 1991; Hillgren et al. 1995). The most suitable method for the study of
drug intestinal transport appeared to be the use of cultured intestinal
epithelial cells...
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