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| Topic: |
Science
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| Number of pages / Number of words: |
8 / 1965 |
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At this site, NPY is contained within neurones in the medial aspect of the nucleus, and is colocalised with another orexigenic peptide, agouti-related peptide (AgRP) [13]. The actions of this pairing of orexigenic peptides is counterbalanced by neighbouring neurones in the same nucleus, which contain anorexigenic peptides pro-opiomelanocortin (POMC) and cocaine and amphetamine regulating transcript (CART)...
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Leptin receptors are present on both of these neuronal types, and the adipocyte-derived peptide, leptin, acts to inhibit NPY/AgRP neurones and to POMC/CART neurones consistent with its role in reducing food intake [14].
NPY is also synthesized in the dorsovagal complex of the medulla, which receives afferent nerves from the gastrointestinal tract...
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