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| Topic: |
Science
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| Number of pages / Number of words: |
6 / 1509 |
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Tat interaction with cells is mediated by a RED motif (cell binding motif), which is represented in HIV-1 but not in HIV-2. Thus, KS is less frequently associated with HIV-2.
HHV-8 is thought to be linked to KS by a homologue of a G-protein coupled receptor encoded by ORF 74 (open reading frame 74)...
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This homologue of G-protein is expressed in some KS tissue, which in turn induces angiogenic cytokine such as VEGF (vascular endothelial growth factor). Thus, expression of the homologue leads to cell growth. Although, VEGF is expressed in KS tumors ORF 74 is not expressed in all KS tumors, which suggests a more complex pathway to expressing VEGF than simply expressing ORF 74...
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