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Science
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| Number of pages / Number of words: |
6 / 1606 |
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If in excess, can cause overwhelming cell growth and division to result in goiter.
Most T3 and T4 released into the bloodstream are bound to proteins. Only the "free" component is biologically active and it is this component which decides the manifestations of thyrotoxicosis. The hormones exert their effects mainly by binding to nuclear receptors in cells to affect expression of genes...
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These receptors facilitate the action of "fight, flight and fright" hormones ( epinephrine, norepinephrine) which are positively chronotropic ( beat faster) and inotropic ( pump harder) to the heart. This may then lead to cardiac failure in older patients.
In fact, mild hyperthyroidism may produce severe disability in patients with underlying heart disease...
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