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| Topic: |
Science
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| Number of pages / Number of words: |
3 / 778 |
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What do you notice about the size of the binding site relative to that of the natural neurotransmitter?
As discussed in a previous question we can clearly see where the catechol group of noradrenaline binds to the serine residues present in the receptor site, also the overall size seems to be an excellent fit for a molecule with the approximate size as noradrenaline...
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This tells us that the natural neurotransmitter binds tightly and efficiently to the receptor site, so any molecules/drugs competing for this receptor site would have to be of a similar size and would also need to have significantly better binding interactions with the residues that make up the receptor binding site...
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