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| Topic: |
Science
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| Number of pages / Number of words: |
18 / 4989 |
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Both termini of the genomic RNA contain 5' untranslated region (UTR) and 3'UTR sequences that do not encode viral proteins (Pei-Yong et al, 2001). Viral and cellular proteases translated and co- and posttranslationally processed that encode a single long polyprotein into three structural proteins, namely the capsid (C), premembrane (prM) or membrane (M), and envelope glycoprotein (E) and followed by seven nonstructural proteins NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5 in that order...
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These findings suggest that replacing the genes for the viral structural proteins in a full-length infectious cDNA clone of a flavivirus with the corresponding viral genes of another flavivirus could produce the viable virus. Test had been successfully conducted with chimeras that contained the sequence for viral structural proteins preM and E of tick-borned encephalitis virus (TBEV) or tick-borned Langat virus (LGT)...
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