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First, with reams of new data in the literature and the resultant emergence of novel concepts, I would expect a long textbook (448 pages) on the basis of breast cancer to include a wide-ranging and in-depth look at its molecular control. We know that cancer is largely due to genomic instability that arises within populations of (as yet undefined) stem cells, and involves the escape of protective apoptosis and immune surveillance mechanisms, deregulated proliferation, and inappropriate sampling of the environment so that tumour cells ignore normal positional cues and thereby migrate to and survive at distant metastatic sites...
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We know that cancer is largely due to genomic instability that arises within populations of (as yet undefined) stem cells, and involves the escape of protective apoptosis and immune surveillance mechanisms, deregulated proliferation, and inappropriate sampling of the environment so that tumour cells ignore normal positional cues and thereby migrate to and survive at distant metastatic sites...
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EDGAR ALLAN POE AND BREAST CANCER
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